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Research

Al-Hendy Laboratory

Al-Hendy Laboratory

Overview

The Al-Hendy laboratory uses methods of basic, translational, clinical, and community-based research to address important medical diseases. Areas of research focus include the developmental origin of gynecologic conditions, such as uterine fibroids, endometriosis, and infertility. The Al-Hendy lab also develops and investigates the efficacy of novel, non-surgical treatment options for uterine fibroids, endometriosis, and more.

Currently, the Al-Hendy research team is developing innovative therapeutics against female infertility using mesenchymal stem cells and/or its exosomes. The lab's research is funded by various agencies, including several R01 grants from the NIH (NICHD, NIEHS, NIMHD, ODS, OD, NCRR), USDA, other national and international organizations as well as pharmaceutical collaborative research agreements and contracts.

 

Main projects in the laboratory

  1. Studying the efficacy of various nutritional supplements as possible non-surgical therapy options for individuals with uterine fibroids. Currently, the lab is conducting studies on the efficacy of EGCG (green tea extract) as an alternative to surgery for patients with uterine fibroids. The Al-Hendy lab also investigates the contribution of vitamin D deficiency in fibroid development as well as the use of vitamin D as a therapeutic option for uterine fibroids. 
  2. Characterizing stem cells from human and rat tissue samples to understand the role of developmental epigenetic and epitranscriptomics reprogramming and early life adverse environmental exposures in adult-onset uterine fibroids.
  3. Utilizing human mesenchymal stem cells to treat animal models of female infertility (with a primary focus on premature ovarian insufficiency and polycystic ovary syndrome) and translating the findings to innovative human clinical trials.

 

Collaboration

To reach our goals our lab collaborates with physicians and scientists from around the world. 

 

Funding

The Al-Hendy lab receives substantial funding from various public and private organizations. 

 

Publications

Publishing research findings is a top priority in the lab, with Dr. Al-Hendy and co-investigators having published more than 200 peer-reviewed publications in top-tier scientific journals, including the New England Journal of Medicine, Obstetrics and Gynecology, Fertility and Sterility, and more. 

 

Podcast Features

 

Laboratory Awards & Leadership

 

ayman al hendy

Ayman Al-Hendy, MD, PhD

Professor of Obstetrics and Gynecology

Uterine Fibroid Treatment & Research News

The Department of Obstetrics and Gynecology