Research Summary:
The Challa Laboratory at the University of Chicago is committed to advancing our understanding of the molecular mechanisms and functions of gynecologic cancers to aid the development of novel therapeutic strategies that can improve the lives of women with gynecologic cancer. The laboratory is directed by Sridevi Challa, PhD – an Assistant Professor of Obstetrics and Gynecology whose work focuses on the role of NAD+ metabolism and mRNA translation in gynecologic cancer pathogenesis.
Dr. Challa is also developing the Endometrial Cancer Research Program at the University of Chicago alongside Drs. Gini Fleming, John Moroney, and Katherine Kurnit.
Main projects in the laboratory:
- Advance our understanding of the molecular mechanisms and function of metabolic regulation and protein homeostasis in ovarian cancer to develop novel therapeutic strategies
- Identify mechanisms of therapeutic resistance in ovarian cancer
- Develop the Endometrial Cancer Research Program
Collaborations:
- Lengyel/Kenny (Ovarian Cancer) Laboratory, University of Chicago
- Dr. Kunle Odunsi, The University of Chicago Comprehensive Cancer Center
- Dr. Gini Fleming, Hematology/Oncology, University of Chicago
- Dr. John Moroney, Gynecologic Oncology, Gynecologic Oncology Clinical Trials Program Leader, University of Chicago
- Dr. Katherine Kurnit, Gynecologic Oncology, University of Chicago
Featured Publications:
- Challa S. et al. Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo. eLife. 11:e72464. April 2022.
- Challa S. et al. Ribosome ADP-ribosylation inhibits translation and maintain proteostasis in cancer. Cell. 184:17, 453104546.e26. August 2021.
- Challa S. et al. MARTs and MARylation in the Cytosol: Biological Functions, Mechanisms of Action, and Therapeutic Potential. Cells. 2021 Feb 3;10(2):313.
- Full list of publications
Sridevi Challa, PhD
Assistant Professor of Obstetrics and Gynecology
