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Research

Challa Laboratory

Challa Lab

Research Summary: 

The Challa Laboratory at the University of Chicago is committed to advancing our understanding of the molecular mechanisms and functions of gynecologic cancers to aid the development of novel therapeutic strategies that can improve the lives of women with gynecologic cancer. The laboratory is directed by Sridevi Challa, PhD – an Assistant Professor of Obstetrics and Gynecology whose work focuses on the role of NAD+ metabolism and mRNA translation in gynecologic cancer pathogenesis.

Dr. Challa is also developing the Endometrial Cancer Research Program at the University of Chicago alongside Drs. Gini Fleming, John Moroney, and Katherine Kurnit.

Main projects in the laboratory:

  1. Advance our understanding of the molecular mechanisms and function of metabolic regulation and protein homeostasis in ovarian cancer to develop novel therapeutic strategies
  2. Identify mechanisms of therapeutic resistance in ovarian cancer
  3. Develop the Endometrial Cancer Research Program

 

Collaborations:

 

Featured Publications: 

 

Sridevi Challa, PhD

Assistant Professor of Obstetrics and Gynecology

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Cancer Ranked No. 14 in the country & High Performing in Ovarian Cancer Surgery in 2022-2023 U.S. News & World Report rankings

U.S. News & World Report ranks 10 University of Chicago Medical Center specialties among the best in the country

The Department of Obstetrics and Gynecology