Lengyel Lab

Lengyel Lab Members

  

Sarah Ackroyd, MD, MPH

  • Dr. Ackroyd focuses her research efforts on the female single cell atlas project, which utilizes single-cell RNA and ATAC sequencing to map and identify the various cell types of the human uterus.
  • Education: BS Biochemistry & BA Statistics, University of Rochester; MPH, University of Buffalo; MD, University of Rochester
  • Publications

Sayed Alhunayan

  • Sayed's research focuses on the isolation of primary fibroblasts, lymphocytes and myeloid cells; gene expression analysis with qPCR; and immune cell population analysis with flow cytometry. 
  • Education: B.Sc in Biochemistry and Molecular Biology, Dalhousie University, Canada

Sarah Ashley

  • Works with Dr. Pascul Bus on studying the interaction between ovarian cancer cells, stromal cells, and cells of the innate immune system, with a specific interest in natural killer cells.
  • Education: Boston College

Pretty Bajwa, PhD

  • Currently working with Dr. Kenny to characterize the tumor-promoting role of mesothelial cells in different stages of ovarian cancer metastasis in vivo.
  • Dr. Bajwa received her PhD in from the University of Newcastle, Australia for her work on age-related mTOR signaling in gynecological cancers.

Sanaa Nakad Borrego, MD

  • Dr. Borrego is working on ovarian and uterine carcinosarcoma, the tumor immune-microenvironment, and epithelial-mesenchymal-transition (EMT). 
  • Medical school: American University of Beirut, Lebanon

Natalie Bourand

Pascal Bus, PhD

  • Dr. Bus is interested in the interaction between ovarian cancer cells, stromal cells, and cells of the innate immune system, with a specific interest in natural killer cells.
  • He received his PhD in the involvement of the innate immune system in the development of diabetic nephropathy from Leiden University Medical Center in the Netherlands. 
  • Publications

Rohin Dhir, MD

  • Dr. Dhir assists in both clinical and basic research studies by consenting patients, collecting and processing bio-specimens, and linking to clinico-pathological data
  • Medical school: Aureus University, Canada

Johnny Garcia

Janna Heide, MD

  • Dr. Heide is investigating the effect of cancer-associated fibroblasts on immune cell infiltration and function in ovarian cancer. Her research is focused on the expression of Nicotinamide-N-Methyltransferase (NNMT) in fibroblasts that influences the response to therapy and alters the immune phenotype in the tumor microenvironment.
  • Medical school: University of Hamburg, Germany
  • Current Grants: German Research Foundation (DFG)
  • Publications

Hilary Kenny, PhD

  • Co-directs lab with Dr. Ernst Lengyel
  • Dr. Kenny primarily focuses on the role of the tumor microenvironment in early ovarian cancer metastasis. Her research specifically focuses on the molecular mechanisms involved in ovarian cancer adhesion, invasion, metabolic activity and proliferation, including adhesive molecules, proteases and extracellular matrices. 
  • Current grants: 
  1. Bears Care Pilot Project Grant. PI: Ernst Lengyel. Hilary Kenny's Role: Co-Investigator. Title: "Ovarian Cancer Drug Discovery by High Throughput Screening with a Three-Dimension (3D) Culture." Project Period: 01/01/2022-12/31/2022. 
  2. AbbVie-UChicago Collaboration (RFP) 2021. PI: Hilary Kenny and Ernst Lengyel. Title: “Defining the Heterogeneous Immune Landscape of the Ovarian Cancer Tumor Microenvironment.” Project Period: 12/20/2021-12/19/2024. 
  3. UCCCC Team Science Award- PI: Jing Chen. Hilary Kenny's Role: Co-PI. Title: “Metabolism-related mechanisms underlying PARPi response and resistance in ovarian cancer cells and the tumor microenvironment.” Project Period: 07/01/2021-06/30/2023. 
  4. Arsenalbio- PI: Ernst Lengyel. Hilary Kenny's Role: Co-Investigator. Title: “Delineating the Ovarian Cancer Tumor Microenvironment: A Single-Cell Perspective.” Project Period: 07/01/2020-06/30/2023. 
  5. Ovarian Cancer Research Alliance Collaborative Research Development Grant. PI: Ugo Cavallaro. Co-PI: Ernst Lengyel, and Francis Balkwill. Hilary Kenny's Role: Co-Investigator. Title: “Interplay between ovarian cancer stem cells and the tumor microenvironment: Mechanisms, biological implications and therapeutic opportunities.” Project Period: 01/01/2020-12/31/2022. 
  • Dr. Kenny received her PhD in Neurobiology and Physiology at Northwestern University and completed her postdoctoral fellowship in Ovarian Cancer Biology, Tumor Microenvironment and Metastasis at the University of Chicago. She completed her bachelor's in biology at Washington College in Chestertown, Maryland. 
  • Publications

Kasjusz Kordylewicz

  • On-going projects:
    1. Mesothelial Cell Project: Study the role of mesothelial cells and how they aid in the progression and metastasis of ovarian cancer
    2. Combinatorial Screen: High-throughput screening to discover compounds targeting ovarian cancer stem cells
  • Education: Loyola University Chicago, Bachelor’s in Biology
  • Publications

Rahul Krishnan, MD

  • Dr. Krishnan focuses on understanding the precursors of ovarian cancer. He currently has two on-going projects:
  1. Project utilizing spatial transcriptomics and proteomics to understand the pathophysiology of serous tubal intra-epithelial carcinoma (STIC) and its evolution to high grade serous ovarian cancer. He is working in collaboration with Dr. Mann’s group at the Max Planck Institute in Munich.
  2. Single cell atlas project: Dr. Krishnan's work utilizes single-cell RNA and ATAC sequencing to map and identify the various cell types of the human uterus.
  • Dr. Krishnan received his medical degree from Weill Cornell Medical College and completed his residency in obstetrics and gynecology at the University of Virginia. He earned his BA at Cornell University. 
  • Publications

Dahlya Manning

Paul Miller

  • Paul is currently investigating the role of natural killer (NK) cells in ovarian cancer in a 3D spheroid model.
  • Education: Howard University, Bachelor of Science

Abir Mukherjee, PhD

  • Dr. Mukherjee is interested in the effect of the tumor microenvironment on ovarian cancer metastasis. 
  • Publications 

Rohit Nagare, PhD

  • Dr. Nagare's research focuses on ovarian cancer stem cells.
  • He received his PhD in ovarian cancer and stem cells from the University of Madras, India; his MSc in medical biotechnology from Pravara Institute of Medical Sciences, India; and his bachelor’s in pharmaceutical sciences from the University of Pune, India. 
  • Publications

Melanie Weigert, PhD

  • Dr. Weigert is working to identify the origin of ovarian cancer using Next-Generation Sequencing.
  • She received her PhD from the University of Glasgow in Cancer Research while working on oncolytic adenoviruses and how they induced cytotoxicity in cancer. 

Roni Yoeli-Bik, MD

  • Dr. Yoeli-Bik is interested in investigating the ultrasound characteristics of adnexal masses in favor of accurate preoperative discrimination between benign and malignant lesions.
  • Medical School: The Hebrew University of Jerusalem, Hadassah Medical School, Israel (B.Med.Sc., Magna Cum Laude) 
  • *Hirshoren, N., *Yoeli, R., Cohen, J. E., Weinberger, J. M., Kaplan, N., Merims, S., Peretz, T., & Lotem, M. (2020). Checkpoint inhibitors: Better outcomes among advanced cutaneous head and neck melanoma patients. PloS one, 15(4), e0231038. *Equal contribution

Malu Zandbergen

  • Malu is interested in the effect of the tumor microenvironment on ovarian cancer metastasis.
  • Education: Bachelor of Science, University of Applied Sciences Leiden, The Netherlands
  • Publications

Time Period in the Lab

Name

Position in the Lab

Position obtained after training

 2014-2021

Chun-Yi Chiang, MS

Research Specialist II

Cellular Screening Center, University of Chicago

2019 – 2021

Katarzyna Zawieracz

Technician

PhD student, Cancer Biology Program, University of Chicago

2018-2021

Patricia Dauer, PhD

Postdoctoral Fellow

Scientist, Biotech

2013-2021

Mark Eckert, PhD

Postdoctoral Fellow

Promoted to Research Assistant Professor at the University of Chicago, current VP at a biotech company in San Diego, CA

2018-2021

Carman Ip, PhD

Postdoctoral fellow

Director, High Throughput Screening Core, University of Chicago

2019-2020

Aliaksandra (Sasha) Irhashava

Student – Fulbright Scholar

Continued PhD at Warsaw University

2018-2019

Helen Daifotis

MS III one year research

Resident, OB/GYN, Columbia University

2015-2019

Peter Hart, PhD

Postdoctoral Fellow

Assistant Professor (tenure track), Roosevelt University

2017-2019

Dominik Nahotko

Technician

PhD student, Cancer Biology Program, Northwestern University

2016-2019

Claire Hoppenot

Gynecologic Oncology Fellow

Attending, Baylor College of Medicine

2015 – 2018

Agnieszka Chryplewicz

Master's student, Technician

PhD student, Cancer Biology Program, ESPL Lausanne