Could starving ovarian cancer cells of fat block its deadly spread?

Synopsis: Ovarian cancer can be a devastating disease because it is often not found until it has spread beyond the ovaries to other tissues. It is different from other cancer types because it likes to spread to adipose tissue (body fat), like the abdomen’s fatty area, which provides a rich energy source for these cancer cells. Understanding the biology of ovarian tumors, including why they seem to prefer fatty tissue and how these tumor cells absorb and use fats for energy, is critical to figuring out how to starve these tumor cells and prevent them from spreading. Physicians-scientists from the University of Chicago Medicine Comprehensive Cancer Center Ernst Lengyel, MD, PhD, Professor and Chair of the Department of Obstetrics and Gynecology, and Iris Romero, MD, Professor of Obstetrics and Gynecology, are unraveling this complex biology to understand ovarian cancer and block its spread.

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The Department of Obstetrics and Gynecology